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Anatomic Causes Of Recurrent Pregnancy Losses
By Eric Daiter, M.D.

Implantation and development of a human embryo requires both space and an abundant blood supply. Normally both are readily available within the uterine cavity. In the nonpregnant state, the uterine cavity is primarily a potential space (with a 5-10 milliliter volume) between the anterior and posterior muscular walls of the uterus. Under pressure (such as during operative hysteroscopy) the uterine muscular walls can be distended to about 10-30 milliliters. During pregnancy, the walls of the uterus rapidly adapt to increase the intracavitary volume for the developing fetus. The ability of the uterine walls to adapt is largely due to the muscular composition and ample blood supply. In conditions that compromise either the muscular composition of the uterus or its blood supply there is a tendency for recurrent pregnancy loss. An estimated 15% of couples (1 in 6) with recurrent pregnancy loss have an anatomic abnormality of the uterus as the primary reason. The four categories of anatomic defects that cause recurrent pregnancy loss are abnormalites in:

1. Defects in uterine fusion and resorption
The normal process of uterine fusion during embryonic development
(Mullerian duct abnormalities)

2. DES exposure in utero
The development of the uterus and cervix due to maternal diethylstilbestrol (DES) ingestion

3. Abnormalities in uterine circulation
The size of or circulation to the uterus due to fibroids, endometrial polyps or scar tissue (Ashermann's syndrome)

4. Abnormal cervical function
The function of the cervix.

Dr. Eric Daiter graduated from the University of Pennsylvania, where he was awarded an academic scholarship and was enlisted into the University Scholar's Program and the Benjamin Franklin Scholar's Program.

Dr. Daiter graduated medical school at Temple University Medical School in Philadelphia and completed the Obstetrics and Gynecology residency program at Albert Einstein College of Medicine in New York. He completed his Reproductive Endocrinology and Infertility fellowship at the Hospital of the University of Pennsylvania. He has considered a career as a physician scientist in research medicine and has published several articles on molecular events that occur during the human embryo's implantation into the uterus. Dr. Daiter entered private practice in 1994, where he joined a successful referral based infertility practice and further developed his clinical skills. Dr. Daiter emphasizes the basic principles of infertility patient care, including the importance of highly personalized, cost considerate, state of the art, one on one care for his patients. He specializes in all aspects of In Vitro Fertilization, with a patient success rate among the highest in the state. He has performed several hundred advanced operative laparoscopic and hysteroscopic surgeries, utilizing the most modern laser techniques.

Dr. Daiter opened his Edison, NJ office in 1997. The office continues to support the highest level of professional care for infertile couples. Extended office hours are available for patient convenience.

Eric Daiter, M.D.
34-36 Progress Street
Suite B-4
Edison, New Jersey, 08820

Web Site URL:
Phone: (908) 226-0250
Fax: (908) 226-0830

The information presented in these articles are offered for informational purposes only. These pages have been written by Dr. Eric Daiter, yet are not intended to replace the medical advise offered by your personal physicians or healthcare professionals.

All rights reserved. No part of the material protected by this copyright notice may be reproduced or utilized in any form, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without written permission from the copyright owner.


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