What is metformin used for in infertility treatments?

Metformin, also known as Glucophage, is a medication used for Type 2 diabetes. Metformin is taken orally. Metformin helps the body respond better to insulin; this then helps the body metabolize the sugar glucose.

The female reproductive system, particularly the ovaries, requires insulin to work properly. When there is an excess of insulin in the body, the ovaries may not function normally. Thus, there is a basic relationship between insulin and pregnancy. This relationship becomes especially important for women with PCOS.

PCOS (Polycystic Ovarian Syndrome) is a common cause of infertility. The ovaries of women with PCOS contain many small cysts, hence the name “polycystic.” Women with PCOS often do not ovulate regularly and have irregular menstrual cycles.

Many physicians and fertility experts attempt to treat PCOS with a drug called clopimhene or Clomid. Clomid helps to induce ovulation. In recent years, Metformin has been used, either with or without Clomid, to help produce ovulation in women with PCOS. Metformin assists the body with responding to and managing its insulin; in turn, this helps the ovaries function more regularly, and creates a more regular ovulation cycle. This assists greatly when trying to conceive.

Some studies have suggested that the use of metformin also can help reduce the risk of miscarriage. Additionally, the use of metformin may reduce the risk of gestational diabetes, and may delay or prevent the onset of Type 2 diabetes.

Side effects of metformin can include abdominal pain or cramping, discomfort, and nausea. The use of metformin may inhibit the absorption of Vitamin B12. Your physician may recommend vitamin supplements and/or dietary changes to accompany the use of metformin.

Posted in PCOS, Trying to Get Pregnant